IVD reagent material Cardiac marker

Cardiac Troponin I (cTnI) ndi gulu laling'ono la banja la troponin lomwe limagwiritsidwa ntchito ngati chizindikiro cha kuwonongeka kwa myocardial.Cardiac troponin I ndi yeniyeni ya minofu ya mtima ndipo imapezeka mu seramu pokhapokha ngati kuvulala kwa myocardial kwachitika.Chifukwa cardiac troponin I ndi chizindikiro chodziwika kwambiri komanso chodziwika bwino cha kuwonongeka kwa minofu ya mtima (myocardium), ma seramu a seramu angagwiritsidwe ntchito kuthandizira kusiyanitsa pakati pa angina wosakhazikika ndi myocardial infarction (kugunda kwa mtima) mwa anthu omwe ali ndi ululu pachifuwa kapena matenda aakulu.

Mtima wa isoform wa TnT umagwiritsidwa ntchito kwambiri ngati chizindikiro cha kuvulala kwa myocardial cell, monganso cTnI.cTnT ili ndi ma kinetics omwe amamasulidwa m'magazi komanso kukhudzidwa komweko kwa kuvulala kochepa kwa myocardial monga cTnI.M'magazi a odwala acute myocardial infarction (AMI), cTnT nthawi zambiri imapezeka mwaulere pamene cTnI imapezeka kwambiri ndi TnC.

Troponin C, yomwe imadziwikanso kuti TN-C kapena TnC, ndi puloteni yomwe imakhala mu troponin complex pa actin thin filaments of striated muscle (mtima, chigoba chofulumira, kapena chigoba chapang'onopang'ono). kukangana kwa minofu.Troponin C imasungidwa ndi jini ya TNNC1 mwa anthu pamtima komanso minofu yapamtima.

myoglobin ndi mapuloteni a cytoplasmic omwe amamanga mpweya pa gulu la heme.Lili ndi gulu limodzi lokha la globulin, pamene hemoglobini ili ndi anayi.Ngakhale kuti gulu lake la heme ndi lofanana ndi la Hb, Mb ili ndi kuyanjana kwakukulu kwa okosijeni kuposa momwe hemoglobin imakhalira.Kusiyana kumeneku kumagwirizana ndi ntchito yake yosiyana: pamene hemoglobini imanyamula mpweya, ntchito ya myoglobin ndiyo kusunga mpweya.

Digoxin amagwiritsidwa ntchito pochiza kulephera kwa mtima, nthawi zambiri limodzi ndi mankhwala ena.Amagwiritsidwanso ntchito pochiza mitundu ina ya kugunda kwa mtima kosakhazikika (monga matenda osakhazikika a atrial fibrillation).Kuchiza kulephera kwa mtima kungakuthandizeni kuti muziyenda bwino komanso kuchita masewera olimbitsa thupi komanso kulimbitsa mtima wanu.Kuchiza kugunda kwa mtima kosakhazikika kungathandizenso kuti mukhale ndi luso lochita masewera olimbitsa thupi.Digoxin ali m'gulu la mankhwala otchedwa cardiac glycosides.Zimagwira ntchito pokhudza mchere wina (sodium ndi potaziyamu) mkati mwa maselo a mtima.Zimenezi zimachepetsa kupsyinjika kwa mtima ndi kuuthandiza kukhalabe ndi kugunda kwabwino, kokhazikika, ndi kwamphamvu.

CK-MB mu acute myocardial infarction (AMI), ndi CK-BB mu kuwonongeka kwa ubongo ndi chotupa choopsa cha gastro-intestinal thirakiti.CK-MB imayezedwa ndi zochita za ma enzyme kapena kuchuluka kwa kuchuluka kwake ndipo imayesedwa ngati cholembera osati pakuzindikira kwa AMI komanso kukayikira kwa AMI ndi angina wosakhazikika.

Mtundu wamtima-Fatty-Acid-Binding-Protein (hFABP) ndi puloteni, yomwe imakhudzidwa ndi kayendedwe ka myocardial intracellular (Bruins Slot et al., 2010; Reiter et al., 2013).Pambuyo pa matenda a myocardial necrosis hFABP imatulutsidwa mofulumira m'magazi ndipo inafufuzidwa ngati chizindikiro cha AMI.Komabe, chifukwa cha kukhudzika kochepa komanso kutsimikizika kwa hFABP sikunatsimikizidwe kukhala kothandiza, poyerekeza ndi magwiridwe antchito a hs-Tn assays (Bruins Slot et al., 2010; Reiter et al., 2013).

Lipoprotein-Associated Phospholipase A2(Lp-PLA2)

Ma lipids ndi mafuta m'magazi anu.Ma lipoproteins ndi kuphatikiza kwamafuta ndi mapuloteni omwe amanyamula mafuta m'magazi anu.Ngati muli ndi Lp-PLA2 m'magazi anu, mukhoza kukhala ndi mafuta ochuluka m'mitsempha yanu yomwe ili pachiopsezo chophulika ndikuyambitsa matenda a mtima kapena sitiroko.

D-dimer (kapena D dimer) ndi mankhwala owononga fibrin (kapena FDP), kachigawo kakang'ono ka mapuloteni kamene kamakhala m'magazi pambuyo powonongeka kwa magazi ndi fibrinolysis.Amatchedwa choncho chifukwa ali ndi tizidutswa ta D tiwiri ta puloteni ya fibrin yolumikizana ndi cholumikizira.