Pa Novembara 9, 2021, mtundu wina wakachilombo ka corona katsopanoB.1.1.529 inapezedwa koyamba kuchokera ku chitsanzo cha mlandu wa ku South Africa.Pasanathe milungu iwiri, mtundu wa mutant unakhala mtundu waukulu kwambiri wa matenda atsopano a koronavirus ku South Africa, ndipo kukula kwake kwadzetsa chidwi padziko lonse lapansi.Pa Novembara 26, mtundu wosinthika uwu wafotokozedwa ndi WHO ngati "mitundu yachisanu" (VOC), yotchedwa Omicron (Omicron) mutant.Pakadali pano, mtundu wa Omicrom wafalikira mwachangu kumayiko kapena zigawo 19 padziko lonse lapansi, ndipo ukhoza kubweretsa zovuta zatsopano pakupewa ndi kuwongolera miliri yapadziko lonse lapansi.
WHO inanenanso kuti Omicron ali ndi masinthidwe ambiri, ena omwe ali ndi nkhawa.Bungwe la WHO linanenanso kuti mtundu wa "Omicron" mutant umadziwika mwachangu kuposa mitundu ina yosinthika yomwe idayambitsa matenda ambiri m'mbuyomu, zomwe zikuwonetsa kuti mtundu waposachedwa wa mutant ukhoza kukhala ndi mwayi wokulirapo.Kuteteza mwamphamvu kufalikira kwa zovuta za mutant za coronavirus yatsopano Omicron yakhala chandamale chatsopano chopewera miliri yapadziko lonse lapansi.
Mapu ogawa osinthika a Omicron(1）ndi Delta(2）, Stanford University Coronavirus and Drug Resistance Database
Kuphatikiza pa kukhala ndi masinthidwe ochulukirapo mu protein ya spike, mtundu wa Omicron mutant ulinso ndi malo angapo osinthika mu protein ya N.Popeza chandamale chachikulu cha chowunikira chatsopano cha coronavirus antigen ndi puloteni ya N, kusintha kwa mapuloteni a N kungakhudze antigen yatsopano ya coronavirus.Kulondola kwa zida zoyeserera kumakhala ndi zotsatirapo.
| Table 1. Kuyerekeza kwa kusintha kwa mapuloteni a N amitundu yosiyanasiyana
| |
| Kachilombo
| N kusintha kwa protein |
| Alfa(B.1.1.7) | Mtengo wa R203K;G204R (> 50%) S194L(5-50%) D3H;D63G;T205I;M234I(1-5%) |
| Beta (B.1.351) | T205I (> 50%) P13S;T3621(5-50%) Q9H;Q28R;A35T;E38V;Q418H (1-5%) |
| Gamma (p.1) | P80R;S202C;R203K;G204R (>50%) A211S;D402Y;S4131 (1-5%) |
| Delta(B.1.617.2) | D63G;R203M;G215C;D377Y (>50%) Q9L(>5-50%) G18V;R385K (1-5%)
|
| Omicron(B.1.1.529) | P13L;R203K;G204R Chithunzi cha E31/R32/S33 |
Poyerekeza ndi mapuloteni a Alpha-N, mapuloteni a Omicron-N ali ndi kusiyana kwa malo 10 amino acid.Kuti tifufuze momwe puloteni ya Omicron-N ikugwiritsidwira ntchito ndi anti-covid-19 antibody ya Keygen gene, tidakonza zophatikizanso puloteni ya Omicron-N koyamba, Ndipo tidatsimikiziranso mgwirizano ndi Keygen Gene ndi makasitomala angapo.Zotsatira zikuwonetsa kuti mawonekedwe otseguka a jini yatsopano ya antibody ali ndi zotsatira zofananira za protein ya Omicron-N, mapuloteni a Alpha-N ndi mapuloteni a Delta-N.Mawonekedwe otseguka amtundu watsopano wa antibody atha kutsimikizira kulondola kwa zida zatsopano za virus antigen kuti zizindikire mitundu ya Omicron..
| Table 2 Zotsatira zakuzindikira kwa Omicron recombinant N protein ndi neocorona antibody | ||||||
| Antibody Zophatikizana | Alpha-Nprotein | Omicron-Nprotein | ||||
| 4.0ng/ml | 2.0ng/ml | 1.0ng/ml | 4.0ng/ml | 2.0ng/ml | 1.0ng/ml | |
| Plan 1 | G5 | G4 | G2 | G5 | G4 | G2 |
| Plan 2 | G5 | G4 | G2 | G5 | G4 | G2 |
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Nthawi yotumiza: Dec-14-2021
